Senior Scientist/Principal Scientist- Biotransformation/Met ID

Company: Frontage Laboratories
Location: Exton
Posted on: February 18, 2026

Job Description:

Job Description Job Description Job Title : Senior Scientist / Principal Scientist – Biotransformation/Metabolite Identification. Location : Exton, Pennsylvania Full-time Job Description : We are seeking a highly motivated and experienced Senior Scientist specializing in Biotransformation and Metabolite Identification to join our dynamic team. This individual will play a pivotal role in the characterization and identification of drug metabolites, contributing to our understanding of drug metabolism and its impact on drug safety and efficacy. Key Responsibilities : Design, execute, and interpret biotransformation studies to characterize drug metabolites in vitro and in vivo. Develop and optimize sample preparation and analytical techniques for metabolite profiling and identification using state-of-the-art LC-MS/MS and high-resolution mass spectrometry (HRMS). Interact with clients to provide actionable insights on metabolism-related challenges. Prepare and review scientific reports, presentations, and regulatory documents to ensure accuracy and compliance with industry standards. Stay updated on advancements in biotransformation and metabolite identification technologies and methodologies. Qualifications : Ph.D. in Chemistry, Biochemistry, Pharmaceutical Sciences, or a related field . Strong expertise in drug metabolism and biotransformation, with hands-on experience in metabolite identification using LC-MS/MS and HRMS. Knowledge of in vitro (e.g., hepatocytes, microsomes) and in vivo systems for studying drug metabolism. Familiarity with regulatory guidelines (e.g., FDA, EMA) for metabolite safety testing (MIST). Demonstrated ability to analyze and interpret complex mass spectrometry data and provide detailed reports. Excellent communication skills and ability to work collaboratively in a cross-functional team environment. Preferred Skills : Experience with radiolabeled compounds and metabolite profiling. Track record of publications or presentations in the field of drug metabolism or biotransformation. Hand-on experience on Thermo OrbiTrap or Waters Q-TOF. What We Offer : Competitive salary and benefits package. Opportunities for professional growth and development. A collaborative and innovative work environment. Frontage Laboratories Inc. is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, among other things, or status as a qualified individual with disability

Keywords: Frontage Laboratories, Freeport , Senior Scientist/Principal Scientist- Biotransformation/Met ID, Science, Research & Development , Exton, New York